Cat. No. 4452
Chemical Name: 3-[[(3-Amino-3-carboxypropyl)methox
Biological ActivitySelective, irreversible γ-glutamyl transpeptidase (GGT) inhibitor; displays no inhibitory effects on glutamine amidotransferases or asparagine synthetase. Suppresses oxidative stress by inhibiting GGT activation. Prevents ischemia/reperfusion-induced acute kidney injury in rats in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Yamamoto et al (2011) Preventive effect of GGsTop, a novel and selective γ-glutamyl transpeptidase inhibitor, on ischemia/reperfusion-induced renal injury in rats. J.Pharmacol.Exp.Ther. 339 945. PMID: 21937737.
Han et al (2007) Design, synthesis, and evaluation of γ-phosphono diester analogues of glutamate as highly potent inhibitors and active site probes of γ-glutamyl transpeptidase. Biochemistry 46 1432. PMID: 17260973.
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Keywords: GGsTop, supplier, GGsTop, GGT, inhibitors, inhibits, g-GGT, gamma-GGT, γ-GGT, glutamyltransferases, Glutamyl, Transpeptidase, Ischemia, ischaemia, oxidative, stress, Tocris Bioscience, Other Transferase Inhibitor products
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