Org 24598

Cat. No. 4447

Org 24598  C19H20F3NO3 [372198-97-5]

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Chemical Name: N-Methyl-N-[(3R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]-glycine

Biological Activity

Inhibitor of the glial glycine transporter (GlyT1); derivative of Org 24598 (Cat. No. 4035).

Technical Data

Soluble to 10 mM in water with gentle warming and to 100 mM in DMSO
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Chue et al (2013) Glycine reuptake inhibition as a new therapeutic approach in schizophrenia: focus on the glycine transporter 1 (GlyT1). Curr.Pharm.Des. 19 1311. PMID: 23194655.

Brown et al (2001) Discovery and SAR of org 24598-a selective glycine uptake inhibitor. Bioorg.Med.Chem.Lett. 11 2007. PMID: 11454468.

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Citations are publications that use Tocris products.

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Keywords: Org 24598, supplier, Org24598, glial, glycine, transporters, glyt1, inhibitors, inhibits, Tocris Bioscience, Glycine Transporter Inhibitor products

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