Cat. No. 4444
Chemical Name: 4-[4-(4-Methylphenyl)-2-thiazolyl]-
Biological ActivityInhibitor of sterol regulatory element binding protein (SREBP); impairs the activation of SREBP-1 and SREBP-2. Exhibits antiproliferative effects in DU 145 cells independently of IGF-1 signaling (IC50 = 0.1 μM); reverses hyperglycemia in diabetic (ob/ob) mice. Cell permeable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Kamisuki et al (2009) A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. Chem.Biol. 16 882. PMID: 19716478.
Choi et al (2003) Identification of bioactive molecules by adipogenesis profiling of organic compounds. J.Biol.Chem. 278 7320. PMID: 12496288.
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Keywords: Fatostatin A, supplier, sterol, regulatory, element, binding, proteins, SREBPs, SREBP1, SREBP2, inhibition, inhibitors, inhibits, antiproliferatives, 125B11, FatostatinA, Tocris Bioscience, SREBP Inhibitor products
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