Cat. No. 4444
Chemical Name: 4-[4-(4-Methylphenyl)-2-thiazolyl]-
Biological ActivityInhibitor of sterol regulatory element binding protein (SREBP); impairs the activation of SREBP-1 and SREBP-2. Exhibits antiproliferative effects in DU 145 cells independently of IGF-1 signaling (IC50 = 0.1 μM); reverses hyperglycemia in diabetic (ob/ob) mice. Cell permeable.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Kamisuki et al (2009) A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. Chem.Biol. 16 882. PMID: 19716478.
Choi et al (2003) Identification of bioactive molecules by adipogenesis profiling of organic compounds. J.Biol.Chem. 278 7320. PMID: 12496288.
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Keywords: Fatostatin A, supplier, sterol, regulatory, element, binding, proteins, SREBPs, SREBP1, SREBP2, inhibition, inhibitors, inhibits, antiproliferatives, 125B11, FatostatinA, Tocris Bioscience, SREBP Inhibitor products