Cat. No. 4440
Alternative Name: ENA 713
Chemical Name: N-Ethyl-N-methylcarbamic acid 3-[(1S)-1-(dimethylamino)ethyl]phen
Biological ActivityDual cholinesterase inhibitor (ChEI); inhibits both butyrylcholinesterase (BChE) and acetylcholinesterase (AChE). Brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Mehta et al (2012) New acetylcholinesterase inhibitors for Alzheimer's disease. Int.J.Alzheimers Dis. PMID: 22216416.
Bailey et al (2011) Rivastigmine lowers Aβ and increases sAPPα levels, which parallel elevated synaptic markers and metabolic activity in degenerating primary rat neurons. PLoS One 6 e21954. PMID: 21799757.
Groner et al (2007) The kinetics of inhibition of human acetylcholinesterase and butyrylcholinesterase by two series of novel carbamates. Mol.Pharmacol. 71 1610. PMID: 17347320.
Luo et al (2006) Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine. J.Med.Chem. 49 2174. PMID: 16570913.
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Citations are publications that use Tocris products. Selected citations for Rivastigmine tartrate include:
Budzynska et al (2015) Effects of imperatorin on scopolamine-induced cognitive impairment and oxidative stress in mice. Curr Alzheimer Res 232 931. PMID: 25189792.
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