Rivastigmine tartrate

Cat. No. 4440

Rivastigmine tartrate C14H22N2O2.C4H6O6 [129101-54-8]

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Alternative Name: ENA 713

Chemical Name: N-Ethyl-N-methylcarbamic acid 3-[(1S)-1-(dimethylamino)ethyl]phenyl ester (2R,3R)-2,3-dihydroxybutanedioate

Biological Activity

Dual cholinesterase inhibitor (ChEI); inhibits both butyrylcholinesterase (BChE) and acetylcholinesterase (AChE). Brain penetrant.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Mehta et al (2012) New acetylcholinesterase inhibitors for Alzheimer's disease. Int.J.Alzheimers Dis. PMID: 22216416.

Bailey et al (2011) Rivastigmine lowers Aβ and increases sAPPα levels, which parallel elevated synaptic markers and metabolic activity in degenerating primary rat neurons. PLoS One 6 e21954. PMID: 21799757.

Groner et al (2007) The kinetics of inhibition of human acetylcholinesterase and butyrylcholinesterase by two series of novel carbamates. Mol.Pharmacol. 71 1610. PMID: 17347320.

Luo et al (2006) Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine. J.Med.Chem. 49 2174. PMID: 16570913.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Rivastigmine tartrate include:

Budzynska et al (2015) Effects of imperatorin on scopolamine-induced cognitive impairment and oxidative stress in mice. Curr Alzheimer Res 232 931. PMID: 25189792.

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