Cat. No. 4438
Chemical Name: 3-Fluoro-5-[2-(6-methyl-2-pyridinyl
Biological ActivityHigh affinity negative allosteric modulator at the mGlu5 receptor (Ki = 0.67 nM). Potently inhibits mGlu5 glutamate-mediated calcium mobilization (IC50 = 1.22 nM). Inhibits cocaine-taking and cocaine-seeking behavior in rats.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Keck et al (2014) A novel mGluR5 antagonist, MFZ 10-7, inhibits cocaine-taking and cocaine-seeking behavior in rats. Addict.Biol. 19 195. PMID: 24001208.
Keck et al (2012) Metabotropic glutamate receptor 5 negative allosteric modulators as novel tools for in vivo investigation. ACS Med.Chem.Lett. 3 544. PMID: 22924094.
Alagille et al (2011) Potent mGluR5 antagonists: pyridyl and thiazolyl-ethynyl-3,5-disubstituted-phenyl series. Bioorg.Med.Chem.Lett. 21 3243. PMID: 21546249.
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Keywords: MFZ 10-7, supplier, MFZ107, high, affinity, negative, allosteric, modulators, nams, mglur5, metabotropic, glutamate, receptors, nams, Tocris Bioscience, Glutamate (Metabotropic) Group I Receptor Modulator products
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