Cat. No. 4437
Chemical Name: 4-Butoxy-N-(2,4-difluorophenyl)benz
Biological ActivityPositive allosteric modulator of mGlu5 receptors (EC50 = 33 nM). Binds to a site distinct from that bound by MPEP (Cat. No. 1212).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Hammond et al (2010) Discovery of a novel chemical class of mGlu5 allosteric ligands with distinct modes of pharmacology. ACS Chem.Neurosci. 1 702. PMID: 20981342.
If you know of a relevant reference for VU 0357121 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses VU 0357121 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: VU 0357121, supplier, VU0357121, pams, positive, allosteric, modulators, mglu5, receptors, mglur5, Tocris Bioscience, Glutamate (Metabotropic) Group I Receptor Modulator products
Find multiple products by catalog number
New Products in this Area
Stable photoreleaser of L-glutamateTASP 0433864
Selective mGlu2 receptor positive allosteric modulator
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.