Cat. No. 4436

8-Chloroadenosine C10H12ClN5O4 [34408-14-5]

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Chemical Name: 6-Amino-8-chloropurine riboside

Biological Activity

Nucleoside analog; metabolized in vivo to 8-Chloro-ATP. Incorporates into RNA during transcription and inhibits RNA synthesis. Exhibits cytotoxicity in MM.1S, RPMI-8226 and U266 cancer cell lines; induces G2/M cell cycle arrest and mitotic catastrophe in A549 and H1299 cells.

Technical Data

Soluble to 20 mM in water with gentle warming and to 100 mM in DMSO
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Cervantes-Gomez et al (2011) ATP analog enhances the actions of a heat shock protein 90 inhibitor in multiple myeloma cells. J.Pharmacol.Exp.Ther. 339 545. PMID: 21821695.

Gu et al (2006) 8-Chloro-adenosine inhibits growth at least partly by interfering with actin polymerization in cultured human lung cancer cells Biochem.Pharmacol. 72 541. PMID: 16844099.

Zhang et al (2004) Exposure of human lung cancer cells to 8-chloro-adenosine induces G2/M arrest and mitotic catastrophe. Neoplasia 6 802. PMID: 15720807.

If you know of a relevant reference for 8-Chloroadenosine please let us know.

Citations are publications that use Tocris products. Selected citations for 8-Chloroadenosine include:

Kearney et al (2015) 8-Chloroadenosine Sensitivity in Renal Cell Carcinoma Is Associated with AMPK Activation and mTOR Pathway Inhibition. PLoS One 10 e0135962. PMID: 26313261.

Do you know of a great paper that uses 8-Chloroadenosine from Tocris? If so please let us know.

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Keywords: 8-Chloroadenosine, supplier, 8-Cl-Ado, 8-Cl-ATP, cytotoxic, chemotherapeutics, growth, arrest, RNA, synthesis, transcription, inhibitors, inhibits, nucleoside, analogs, Tocris Bioscience, DNA, RNA and Protein Synthesis Inhibitor products

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