Cat. No. 4435
Chemical Name: N-[2-Methyl-3-[[4-[4-[[4-(trifluoro
Biological ActivitySelective blocker of human NaV1.7 channels (IC50 values are 0.17, 0.3, 0.4 and 1.1 μM at hNaV1.7, hNaV1.3, hNaV1.4 and hNaV1.5 respectively). Also inhibits tetrodotoxin-sensitive sodium channels. Displays analgesic efficacy in the formalin pain model.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Bregman et al (2011) Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain. J.Med.Chem. 54 4427. PMID: 21634377.
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Citations are publications that use Tocris products. Selected citations for TC-N 1752 include:
Curtright et al (2015) Modeling nociception in zebrafish: a way forward for unbiased analgesic discovery. PLoS One 10 e0116766. PMID: 25587718.
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Keywords: TC-N 1752, supplier, TCN1752, sodium, channels, blockers, selective, nav1.7, analgesics, Tocris Bioscience, Voltage-gated Sodium (NaV) Channel Blocker products