TC-N 1752

Cat. No. 4435

TC-N 1752 C25H27F3N6O3 [1211866-85-1]

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Chemical Name: N-[2-Methyl-3-[[4-[4-[[4-(trifluoromethoxy)phenyl]methoxy]-1-piperidinyl]-1,3,5-triazin-2-yl]amino]phenyl]acetamide

Biological Activity

Selective blocker of human NaV1.7 channels (IC50 values are 0.17, 0.3, 0.4 and 1.1 μM at hNaV1.7, hNaV1.3, hNaV1.4 and hNaV1.5 respectively). Also inhibits tetrodotoxin-sensitive sodium channels. Displays analgesic efficacy in the formalin pain model.

Technical Data

M.Wt:
516.52
Formula:
C25H27F3N6O3
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in 1eq. HCl
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
1211866-85-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Bregman et al (2011) Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain. J.Med.Chem. 54 4427. PMID: 21634377.

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Citations are publications that use Tocris products. Selected citations for TC-N 1752 include:

Curtright et al (2015) Modeling nociception in zebrafish: a way forward for unbiased analgesic discovery. PLoS One 10 e0116766. PMID: 25587718.

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Keywords: TC-N 1752, supplier, TCN1752, sodium, channels, blockers, selective, nav1.7, analgesics, Tocris Bioscience, Voltage-gated Sodium (NaV) Channel Blocker products

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