Cat. No. 4435
Chemical Name: N-[2-Methyl-3-[[4-[4-[[4-(trifluoro
Biological ActivityHuman NaV channel inhibitor (IC50 values are 0.17, 0.3, 0.4, 1.1 and 1.6 μM at hNaV1.7, hNaV1.3, hNaV1.4, hNaV1.5 and hNav1.9 respectively). Also inhibits tetrodotoxin-sensitive sodium channels. Displays analgesic efficacy in the formalin pain model.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Lin et al (2016) Biophysical and pharmacological characterization of Nav1.9 voltage dependent sodium channels stably expressed in HEK-293 cells. PLoS One. 11. PMID: 27556810.
Bregman et al (2011) Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain. J.Med.Chem. 54 4427. PMID: 21634377.
If you know of a relevant reference for TC-N 1752 please let us know.
Citations are publications that use Tocris products. Selected citations for TC-N 1752 include:
Curtright et al (2015) Modeling nociception in zebrafish: a way forward for unbiased analgesic discovery. PLoS One 10 e0116766. PMID: 25587718.
Do you know of a great paper that uses TC-N 1752 from Tocris? If so please let us know.
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Keywords: TC-N 1752, supplier, TCN1752, sodium, channels, blockers, selective, nav, analgesics, Tocris Bioscience, Voltage-gated Sodium (NaV) Channel Blocker products