Cat. No. 4434
Chemical Name: 3,6-Dibromo-α-[(dimethylamino)methyl
Biological ActivityInhibitor of neural Wiskott-Aldrich syndrome protein (N-WASP) activity. Interacts with the regulatory GTPase-binding domain of N-WASP; inhibits activation of Arp2/3 complex by maintaining N-WASP in an inactive conformation. Also inhibits PIP2-induced actin polymerization (EC50 ~ 4μM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Wegner et al (2008) N-WASP and the Arp2/3 complex are critical regulators of actin in the development of dendritic spines and synapses. J.Biol.Chem. 283 15912. PMID: 18430734.
Guerriero and Weisz et al (2006) N-WASP inhibitor wiskostatin nonselectively perturbs membrane transport by decreasing cellular ATP levels. Am.J.Physiol.Cell Physiol. 292 C1562. PMID: 17092993.
Peterson et al (2004) Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation. Nat.Struct.Mol.Biol. 11 747. PMID: 15235593.
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Citations are publications that use Tocris products. Selected citations for Wiskostatin include:
Rassokhin and Pakhomov (2014) Cellular regulation of extension and retraction of pseudopod-like blebs produced by nanosecond pulsed electric field (nsPEF). Cell Biochem Biophys 69 555. PMID: 24488232.
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Keywords: Wiskostatin, supplier, Arp2/3, complex, n-wasp, wiskott-aldrich, syndrome, inhibitors, inhibits, actin, polymerization, 3,6-Dibromo-a-[(dimethylamino)methyl]-9H-cabazole-9-ethanol, Tocris Bioscience, Actin Inhibitor products
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December 3 - 7, 2016
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