Cat. No. 4434
Chemical Name: 3,6-Dibromo-α-[(dimethylamino)methyl
Biological ActivityInhibitor of neural Wiskott-Aldrich syndrome protein (N-WASP) activity. Interacts with the regulatory GTPase-binding domain of N-WASP; inhibits activation of Arp2/3 complex by maintaining N-WASP in an inactive conformation. Also inhibits PIP2-induced actin polymerization (EC50 ~ 4μM).
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Wegner et al (2008) N-WASP and the Arp2/3 complex are critical regulators of actin in the development of dendritic spines and synapses. J.Biol.Chem. 283 15912. PMID: 18430734.
Guerriero and Weisz et al (2006) N-WASP inhibitor wiskostatin nonselectively perturbs membrane transport by decreasing cellular ATP levels. Am.J.Physiol.Cell Physiol. 292 C1562. PMID: 17092993.
Peterson et al (2004) Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation. Nat.Struct.Mol.Biol. 11 747. PMID: 15235593.
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Citations are publications that use Tocris products. Selected citations for Wiskostatin include:
Rassokhin and Pakhomov (2014) Cellular regulation of extension and retraction of pseudopod-like blebs produced by nanosecond pulsed electric field (nsPEF). Cell Biochem Biophys 69 555. PMID: 24488232.
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Keywords: Wiskostatin, supplier, Arp2/3, complex, n-wasp, wiskott-aldrich, syndrome, inhibitors, inhibits, actin, polymerization, 3,6-Dibromo-a-[(dimethylamino)methyl]-9H-cabazole-9-ethanol, Tocris Bioscience, Actin Inhibitor products
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