TTP 22

Cat. No. 4432

TTP 22 C16H14N2O2S2 [329907-28-0]

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Chemical Name: 3-[[5-(4-Methylphenyl)thieno[2,3-d]pyrimidin-4-yl]thio]propanoic acid

Biological Activity

High affinity, ATP-competitive casein kinase 2 (CK2) inhibitor (IC50 = 0.1 μM, Ki = 40 nM). Displays selectivity for CK2 over JNK3, ROCK1 and MET (no inhibitory effects at 10 μM).

Technical Data

Soluble to 100 mM in DMSO and to 20 mM in ethanol
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Golub et al (2011) Synthesis and biological evaluation of substituted (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids as inhibitors of human protein kinase CK2. Eur.J.Med.Chem. 46 870. PMID: 21276643.

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Keywords: TTP 22, supplier, casein, kinase, 2, CK2, inhibits, inhibitors, selective, high, affinity, ATP, competitive, TTP22, Tocris Bioscience, Casein Kinase 2 Inhibitor products

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