A 1070722

Cat. No. 4431

A 1070722 C17H13F3N4O2 [1384424-80-9]

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Chemical Name: 1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea

Biological Activity

Potent glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 0.6 nM for GSK-3α and GSK-3β). Displays high selectivity (> 50-fold) for GSK-3 over a panel of other kinases tested, including CDK family members. Decreases phosphorylation of microtubule-associated protein Tau in vitro; protects rat primary cortical neurons against β amyloid and glutamate challenge. Brain penetrant.

Technical Data

M.Wt:
362.31
Formula:
C17H13F3N4O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
1384424-80-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Bakker et al (2011) A-1070722, a potent, selective, and centrally active glycogen synthase kinase-3 (GSK-3) inhibitor for the treatment of psychiatric and neurodegenerative disorders. Society for Neuroscience (Abstract) 568.

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Keywords: A 1070722, supplier, A1070722, glycogen, synthase, kinases, 3, inhibits, inhibitors, potent, selective, brain, penetrant, neuroprotective, tau, phosphorylation, beta, b, amyloid, Tocris Bioscience, Glycogen Synthase Kinase 3 Inhibitor products

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