BAY 41-2272

Cat. No. 4430

BAY 41-2272 C20H17FN6 [256376-24-6]

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Chemical Name: 5-Cyclopropyl-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-pyrimidinamine

Biological Activity

Activator of soluble guanylyl cyclase (sGC); acts at a nitric oxide (NO)-independent regulatory site in the sGC α1 subunit. Inhibits platelet aggregation (IC50 = 36 nM) and phenylephrine-induced contractions of rabbit aorta (IC50 = 0.30 μM). Also reduces vascular smooth muscle growth through cAMP- and cGMP-dependent PKA and PKG pathways.

Technical Data

M.Wt:
360.39
Formula:
C20H17FN6
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
256376-24-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Joshi et al (2011) The soluble guanylate cyclase stimulator BAY 41-2272 inhibits vascular smooth muscle growth through the cAMP-dependent protein kinase and cGMP-dependent protein kinase pathways. J.Pharmacol.Exp.Ther. 339 394. PMID: 21825001.

Stasch et al (2010) NO-independent regulatory site on soluble guanylate cyclase. Nature 410 212. PMID: 11242081.

Mittendorf et al (2009) Discovery of Riociguat (BAY 63-2521): a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension. ChemMedChem 4 853. PMID: 19263460.

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Keywords: BAY 41-2272, supplier, activators, soluble, guanylyl, guanylate, cyclases, sGC, BAY41-2272, Tocris Bioscience, Guanylyl Cyclase Activator products

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