MitoPY1

Cat. No. 4428

MitoPY1 C52H53BIN2O5P [1041634-69-8]

Price and Availability

For MitoPY1 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: [4-[4-[3-Oxo-6'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3'-yl]-1-piperazinyl]butyl]triphenyl-phosphonium iodide

Biological Activity

Fluorescent probe for imaging hydrogen peroxide (H2O2) in mitochondria of living cells. Displays enhanced emission at 528 nm in the presence of H2O2. Selective for H2O2 over superoxide, nitric oxide and hydroxyl radical. Detects local increases in H2O2 in an in vitro model of Parkinson's Disease.

Licensing Information

Sold under license from the Regents of the University of California

Technical Data

M.Wt:
954.68
Formula:
C52H53BIN2O5P
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store at -20°C
CAS No:
1041634-69-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
Select another batch:

References are publications that support the products' biological activity.

Guo et al (2013) Two-photon fluorescence imaging of intracellular hydrogen peroxide with chemoselective fluorescent probes. J.Biomed.Opt. 18. PMID: 24084856.

Zhao (2009) Lighting up H2O2: the molecule that is a "necessary evil" in the cell. Angew.Chem.Int.Ed.Engl. 48 3022. PMID: 19165849.

Dickinson and Chang (2008) A targetable fluorescent probe for imaging hydrogen peroxide in the mitochondria of living cells. J.Am.Chem.Soc. 130 9638. PMID: 18605728.

If you know of a relevant reference for MitoPY1 please let us know.

Citations are publications that use Tocris products. Selected citations for MitoPY1 include:

Camaré et al (2015) Oxidized LDL-induced angiogenesis involves sphingosine 1-phosphate: prevention by anti-S1P antibody. Br J Pharmacol 172 106. PMID: 25176316.

Do you know of a great paper that uses MitoPY1 from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: MitoPY1, supplier, supplier, fluorescent, probes, reagents, imaging, mitochondria, living, cells, hydrogen, peroxide, H2O2, selective, oxidative, stress, ROS, reactive, oxygen, species, Tocris Bioscience, Fluorescent Probe products

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

Spring/Summer 2017

New Product Guide (Spring/Summer 2017)

Our New Product guide highlights over 130 new products added in the first half of 2017. View PDF today.

divider line

New Products in this Area

PA Janelia Fluor® 646, SE

Photoactivatable cell permeable fluorescent dye; supplied as NHS ester

PA Janelia Fluor® 549, SE

Photoactivatable cell permeable fluorescent dye; supplied as NHS ester

Cyanine 7, SE

Near-infrared fluorescent dye for labeling of amines

Cyanine 3, SE

Orange fluorescent dye for labeling of amines

FFN 200 dihydrochloride

Selective fluorescent VMAT2 substrate

Janelia Fluor® 646, SE

Cell permeable fluorescent dye; supplied as NHS ester

Janelia Fluor® 549, SE

Cell permeable fluorescent dye; supplied as NHS ester

Sign-up for new product e-alerts
divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.