Cat. No. 4427
Alternative Names: TEI 6720, TMX 67
Chemical Name: 2-[3-Cyano-4-(2-methylpropoxy)pheny
Biological ActivityNon-purine inhibitor of xanthine oxidase (Ki = 1.2 nM). Binds to a channel leading to the enzyme active site; obstructs substrate binding.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Xu et al (2008) Xanthine oxidase inhibition with febuxostat attenuates systolic overload-induced left ventricular hypertrophy and dysfunction in mice. J.Card.Fail. 14 746. PMID: 18995179.
Okamoto et al (2003) An extremely potent inhibitor of xanthine oxidoreductase. Crystal structure of the enzyme-inhibitor complex and mechanism of inhibition. J.Biol.Chem. 278 1848. PMID: 12421831.
Osada et al (1993) Hypouricemic effect of the novel xanthine oxidase inhibitor, TEI-6720, in rodents. Eur.J.Pharmacol. 241 183. PMID: 8243554.
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Citations are publications that use Tocris products. Selected citations for Febuxostat include:
Konishi et al (2015) Febuxostat improves outcome in a rat model of cancer cachexia. Front Cell Neurosci 6 174. PMID: 26136193.
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Keywords: Febuxostat, supplier, TMX67, TEI6720, Febuxostat, xanthine, oxidase, oxidoreductase, inhibitors, inhibits, Tocris Bioscience, Other Oxygenase/Oxidase Inhibitor products