Cat. No. 4427

Febuxostat C16H16N2O3S [144060-53-7]

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Alternative Names: TEI 6720, TMX 67

Chemical Name: 2-[3-Cyano-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid

Biological Activity

Non-purine inhibitor of xanthine oxidase (Ki = 1.2 nM). Binds to a channel leading to the enzyme active site; obstructs substrate binding.

Technical Data

Soluble to 75 mM in DMSO and to 50 mM in ethanol
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Xu et al (2008) Xanthine oxidase inhibition with febuxostat attenuates systolic overload-induced left ventricular hypertrophy and dysfunction in mice. J.Card.Fail. 14 746. PMID: 18995179.

Okamoto et al (2003) An extremely potent inhibitor of xanthine oxidoreductase. Crystal structure of the enzyme-inhibitor complex and mechanism of inhibition. J.Biol.Chem. 278 1848. PMID: 12421831.

Osada et al (1993) Hypouricemic effect of the novel xanthine oxidase inhibitor, TEI-6720, in rodents. Eur.J.Pharmacol. 241 183. PMID: 8243554.

If you know of a relevant reference for Febuxostat please let us know.

Citations are publications that use Tocris products. Selected citations for Febuxostat include:

Konishi et al (2015) Febuxostat improves outcome in a rat model of cancer cachexia. Front Cell Neurosci 6 174. PMID: 26136193.

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Keywords: Febuxostat, supplier, TMX67, TEI6720, Febuxostat, xanthine, oxidase, oxidoreductase, inhibitors, inhibits, Tocris Bioscience, Other Oxygenase/Oxidase Inhibitor products

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