Cat. No. 4426
Chemical Name: 6,7,8,9-Tetrahydro-1,6,6-trimethylp
Biological ActivityMajor tanshinone isolated from Salvia miltiorrhiza. Inhibits NF-κB and AP-1 DNA binding. Exhibits cytotoxic activity in a number of different cancer cells. Inhibits β-amyloid aggregation and protects PC12 cells from β-amyloid-induced apoptosis. Displays antioxidant and anti-inflammatory properties.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Dong et al (2012) Tanshinone IIA protects PC12 cells from β-amyloid(25-35)-induced apoptosis via PI3K/Akt signaling pathway. Mol.Biol.Rep. 39 6495. PMID: 22314911.
Jin et al (2008) Tanshinone IIA from Salvia miltiorrhiza BUNGE inhibits human aortic smooth muscle cell migration and MMP-9 activity through AKT signaling pathway. J.Cell Biochem. 104 15. PMID: 17979138.
Lee et al (2008) Anticancer effects of tanshinone I in human non-small cell lung cancer. Mol.Cancer Ther. 7 3527. PMID: 19001436.
Wang et al (2007) Growth inhibition and induction of apoptosis and differentiation of tanshinone IIA in human glioma cells. J.Neurooncol. 82 11. PMID: 16955220.
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Keywords: Tanshinone IIA, supplier, TanshinoneIIA, tanshinone, cytotoxic, inhibitors, inhibits, nf-kappab, nf-kb, nf-κb, ap-1, dna, binding, amyloidbeta, amyloidb, amyloidβ, Tocris Bioscience, NF-κB and IκB Inhibitor products
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