Cat. No. 4426
Chemical Name: 6,7,8,9-Tetrahydro-1,6,6-trimethylp
Biological ActivityMajor tanshinone isolated from Salvia miltiorrhiza. Inhibits NF-κB and AP-1 DNA binding. Exhibits cytotoxic activity in a number of different cancer cells. Inhibits β-amyloid aggregation and protects PC12 cells from β-amyloid-induced apoptosis. Displays antioxidant and anti-inflammatory properties.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Dong et al (2012) Tanshinone IIA protects PC12 cells from β-amyloid(25-35)-induced apoptosis via PI3K/Akt signaling pathway. Mol.Biol.Rep. 39 6495. PMID: 22314911.
Jin et al (2008) Tanshinone IIA from Salvia miltiorrhiza BUNGE inhibits human aortic smooth muscle cell migration and MMP-9 activity through AKT signaling pathway. J.Cell Biochem. 104 15. PMID: 17979138.
Lee et al (2008) Anticancer effects of tanshinone I in human non-small cell lung cancer. Mol.Cancer Ther. 7 3527. PMID: 19001436.
Wang et al (2007) Growth inhibition and induction of apoptosis and differentiation of tanshinone IIA in human glioma cells. J.Neurooncol. 82 11. PMID: 16955220.
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Keywords: Tanshinone IIA, supplier, TanshinoneIIA, tanshinone, cytotoxic, inhibitors, inhibits, nf-kappab, nf-kb, nf-κb, ap-1, dna, binding, amyloidbeta, amyloidb, amyloidβ, Tocris Bioscience, NF-κB and IκB Inhibitor products
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