SR 16584

Cat. No. 4424

SR 16584 C17H22N2O [1150153-86-8]

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Chemical Name: 1,3-Dihydro-1-(3-exo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-2H-indol-2-one

Biological Activity

Selective α3β4 nAChR antagonist (IC50 = 10.2 μM). Selectively binds α3β4 over α4β2 and α7 subtypes (Ki values are 0.508, >100 and >100 μM, respectively).

Technical Data

Soluble to 100 mM in DMSO
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Zaveri et al (2012) Novel α3β4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluation. J.Med.Chem. 53 8187. PMID: 20979364.

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Keywords: SR 16584, supplier, SR16584, nAChRs, nicotinic, acetylcholine, receptors, a3b4, alpha3beta4, α3β4, antagonists, Tocris Bioscience, Nicotinic Receptor (Other Subtype) Antagonist products

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