Cat. No. 4420
Chemical Name: Ethyl 1-(6,7-dimethoxy-1-phthalazinyl)-4-
Biological ActivityAldehyde oxidase (AO) substrate. Exhibits activities as a phosphodiesterase inhibitor; produces concentration-dependent positive inotropic responses in isolated right atria.
Licensing InformationSold for research purposes under agreement from Pfizer Inc.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Hutzler et al (2011) Characterization of aldehyde oxidase enzyme activity in cryopreserved human hepatocytes. Drug Metab.Dispos. 40 267. PMID: 22031625.
Shahid and Rodger et al (1989) Chronotropic and inotropic actions of amrinone, carbazeran and isobutylmethyl xanthine: role of phosphodiesterase inhibition. Br.J.Pharmacol. 98 291. PMID: 2478244.
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Keywords: Carbazeran citrate, supplier, Aldehyde, oxidases, AO, substrates, phosphodiesterase, inhibitors, inhibits, PDE, inotropic, Tocris Bioscience, Other Oxygenase/Oxidase products
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April 22 - 26, 2017
Chicago, IL, USA