Saquinavir mesylate

Cat. No. 4418

Saquinavir mesylate C38H50N6O5.CH4O3S [149845-06-7]

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Alternative Name: Ro 31-8959

Chemical Name: (2S)-N1-[(1S,2R)-3-[(3S,4aS,8aS)-3-[[(1,1-dimethylethyl)amino]carbonyl]octahydro-2(1H)-isoquinolinyl]-2-hydroxy-1-(phenylmethyl)propyl]-2-[(2-quinolinylcarbonyl)amino]butanediamide methanesulfonate

Biological Activity

Inhibitor of human immunodeficiency virus (HIV) protease (Ki values are <0.1 and 0.12 nM for HIV-2 and HIV-1 protease respectively). Exhibits high antiviral activity and low cytotoxicity.

Technical Data

M.Wt:
766.95
Formula:
C38H50N6O5.CH4O3S
Solubility:
Soluble to 50 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
149845-06-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Kaldor et al (1995) Isophthalic acid derivatives: amino acid surrogates for the inhibition of HIV-1 protease. Bioorg.Med.Chem.Lett. 5 721.

Krausslich et al (1992) Specific inhibitor of human immunodeficiency virus proteinase prevents the cytotoxic effects of a single-chain proteinase dimer and restores particle formation. J.Virol. 66 567. PMID: 1727499.

Tucker et al (1992) A series of potent HIV-1 protease inhibitors containing a hydroxyethyl secondary amine transition state isostere: synthesis, enzyme inhibition, and antiviral activity. J.Med.Chem. 35 2525. PMID: 1635054.

Roberts et al (1990) Rational design of peptide-based HIV proteinase inhibitors. Science 248 358. PMID: 2183354.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Saquinavir mesylate include:

Lan et al (2014) Provirus activation plus CD59 blockage triggers antibody-dependent complement-mediated lysis of latently HIV-1-infected cells. J Immunol 193 3577. PMID: 25149467.

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Keywords: Saquinavir mesylate, supplier, hiv, hiv-1, hiv-2, protease, proteinase, inhibitors, inhibits, Ro31-8959, human, immunodeficiency, virus, antivirals, Tocris Bioscience, Other Protease Inhibitor products

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