DBeQ

Cat. No. 4417

DBeQ C22H20N4 [177355-84-9]

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Chemical Name: N2,N4-Bis(phenylmethyl)-2,4-quinazolinediamine

Biological Activity

Selective and reversible inhibitor of p97 ATPase (VCP, IC50 = 1.5 μM). Induces executioner caspases (caspase-3 and caspase-7) rapidly. Blocks the degradation of endoplasmic reticulum-associated degradation (ERAD) reporters; also blocks autophagosome maturation and promotes accumulation of LC3-II.

Technical Data

M.Wt:
340.42
Formula:
C22H20N4
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
177355-84-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Chou et al (2011) Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways. Proc.Natl.Acad.Sci.USA 108 4834. PMID: 21383145.

Chou and Deshaies (2011) Development of p97 AAA ATPase inhibitors. Autophagy 7 1091. PMID: 21606684.

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Citations are publications that use Tocris products.

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Keywords: DBeQ, supplier, DBeQ, aaa, atpases, p97, reversible, reversibly, selective, inhibitors, inhibits, autophagy, erad, endoplasmic-reticulum, associated, protein, degradation, Tocris Bioscience, p97 ATPase Inhibitor products

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