Cat. No. 4417

DBeQ C22H20N4 [177355-84-9]

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Chemical Name: N2,N4-Bis(phenylmethyl)-2,4-quinazolinediamine

Biological Activity

Selective and reversible inhibitor of p97 ATPase (IC50 = 1.5 μM). Induces executioner caspases (caspase-3 and caspase-7) rapidly. Blocks the degradation of endoplasmic reticulum-associated degradation (ERAD) reporters; also blocks autophagosome maturation and promotes accumulation of LC3-II.

Technical Data

Soluble to 100 mM in DMSO
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Chou et al (2011) Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways. Proc.Natl.Acad.Sci.USA 108 4834. PMID: 21383145.

Chou and Deshaies (2011) Development of p97 AAA ATPase inhibitors. Autophagy 7 1091. PMID: 21606684.

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Keywords: DBeQ, supplier, DBeQ, aaa, atpases, p97, reversible, reversibly, selective, inhibitors, inhibits, autophagy, erad, endoplasmic-reticulum, associated, protein, degradation, Tocris Bioscience, Translocation, Exocytosis & Endocytosis products

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