Cat. No. 4417
Chemical Name: N2,N4-Bis(phenylmethyl)-2,4-quinazo
Biological ActivitySelective and reversible inhibitor of p97 ATPase (VCP, IC50 = 1.5 μM). Induces executioner caspases (caspase-3 and caspase-7) rapidly. Blocks the degradation of endoplasmic reticulum-associated degradation (ERAD) reporters; also blocks autophagosome maturation and promotes accumulation of LC3-II.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Chou et al (2011) Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways. Proc.Natl.Acad.Sci.USA 108 4834. PMID: 21383145.
Chou and Deshaies (2011) Development of p97 AAA ATPase inhibitors. Autophagy 7 1091. PMID: 21606684.
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Citations are publications that use Tocris products.
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Keywords: DBeQ, supplier, DBeQ, aaa, atpases, p97, reversible, reversibly, selective, inhibitors, inhibits, autophagy, erad, endoplasmic-reticulum, associated, protein, degradation, Tocris Bioscience, p97 ATPase Inhibitor products