ADX 10059 hydrochloride

Cat. No. 4416

ADX 10059 hydrochloride C15H13FN2.HCl [757949-98-7]

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Chemical Name: 2-[(3-Fluorophenyl)ethynyl]-4,6-dimethyl-3-pyridinamine hydrochloride

Biological Activity

Reported to be a negative allosteric modulator at the mGlu5 receptor. Analog of MPEP (Cat. No. 1212).

Technical Data

Soluble to 25 mM in water and to 100 mM in DMSO
>99 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Weiss et al (2011) 6-Aryl-3-pyrrolidinylpyridines as mGlu5 receptor negative allosteric modulators. Bioorg.Med.Chem.Lett. 21 4891. PMID: 21757343.

Marin and Goadsby (2010) Glutamatergic fine tuning with ADX-10059: a novel therapeutic approach for migraine? Expert Opin.Invest.Drugs 19 555. PMID: 20218930.

Keywood et al (2009) A proof-of-concept study evaluating the effect of ADX10059, a metabotropic glutamate receptor-5 negative allosteric modulator, on acid exposure and symptoms in gastro-oesophageal reflux disease. Gut. 58 1192. PMID: 19460767.

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Keywords: ADX 10059 hydrochloride, supplier, metabotropics, glutamate, receptor, 5, mglur5, mglu5, NAMs, negative, allosteric, modulators, ADX10059, Tocris Bioscience, Glutamate (Metabotropic) Group I Receptor Modulator products

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