Cat. No. 4410
Chemical Name: 2-Pyridinyl[7-(4-pyridinyl)pyrazolo
Biological ActivityModulator of GABAA receptors. Displays modest selectivity for GABAA α1 receptors; displays partial agonist activity at α2-, α3- and α5-containing receptors. Exhibits anxiolytic activity.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Mirza et al (2006) Comparative cue generalization profiles of L-838,417, SL651498, zolpidem, CL218,872, ocinaplon, bretazenil, zopiclone, and various benzodiazepines in chlordiazepoxide and zolpidem drug discrimination. J.Pharmacol.Exp.Ther. 316 1291. PMID: 16339395.
Rupprecht et al (2006) GABAA receptors as targets for novel anxiolytic drugs. World J.Biol.Psychiatry 7 231. PMID: 17071543.
Lippa et al (2005) Selective anxiolysis produced by ocinaplon, a GABAA receptor modulator. Proc.Natl.Acad.Sci.USA 102 7380. PMID: 15870187.
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Keywords: Ocinaplon, supplier, gabaa, α1, alpha1, a1, positive, modulators, anxiolytics, Tocris Bioscience, GABAA Receptor Modulator products