Cat. No. 4410

Ocinaplon C17H11N5O [96604-21-6]

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Chemical Name: 2-Pyridinyl[7-(4-pyridinyl)pyrazolo[1,5-a]pyrimidin-3-yl]methanone

Biological Activity

Modulator of GABAA receptors. Displays modest selectivity for GABAA α1 receptors; displays partial agonist activity at α2-, α3- and α5-containing receptors. Exhibits anxiolytic activity.

Technical Data

Soluble to 100 mM in 2eq.HCl and to 10 mM in DMSO
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Mirza et al (2006) Comparative cue generalization profiles of L-838,417, SL651498, zolpidem, CL218,872, ocinaplon, bretazenil, zopiclone, and various benzodiazepines in chlordiazepoxide and zolpidem drug discrimination. J.Pharmacol.Exp.Ther. 316 1291. PMID: 16339395.

Rupprecht et al (2006) GABAA receptors as targets for novel anxiolytic drugs. World J.Biol.Psychiatry 7 231. PMID: 17071543.

Lippa et al (2005) Selective anxiolysis produced by ocinaplon, a GABAA receptor modulator. Proc.Natl.Acad.Sci.USA 102 7380. PMID: 15870187.

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Citations are publications that use Tocris products.

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Keywords: Ocinaplon, supplier, gabaa, α1, alpha1, a1, positive, modulators, anxiolytics, Tocris Bioscience, GABAA Receptor Modulator products

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