Cat. No. 4408
Chemical Name: N-(2-Methoxy-2-oxoacetyl)glycine methyl ester
Biological ActivityProlyl 4-hydroxylase (P4H) inhibitor; inhibits hypoxia-inducible factor α (HIF-α) prolyl hydroxylase (HIF-PH). Increases levels of HIF-1α; promotes cell survival under hypoxic conditions.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Barnucz et al (2013) Prolyl-hydroxylase inhibition preserves endothelial cell function in a rat model of vascular ischemia reperfusion injury. J.Pharmacol.Exp.Ther. 345 25. PMID: 23388095.
Ayrapetov et al (2011) Activation of Hif1α by the prolylhydroxylase inhibitor dimethyoxalyglycine decreases radiosensitivity. PLoS One 6 e26064. PMID: 22016813.
Lomb et al (2009) Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2α to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2α has a role in NGF-promoted survival of sympathetic neurons. Mol.Pharmacol. 75 1198. PMID: 19204094.
Jaakkola et al (2001) Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292 468. PMID: 11292861.
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Keywords: DMOG, supplier, prolyl, 4-hydoxylase, P4H, inhibitors, inhibits, HIF, hypoxia-inducible, factors, 1a, 1alpha, 1α, proangiogenic, prolylhydroxylases, PHD, Tocris Bioscience, Hydroxylase Inhibitor products
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