Cat. No. 4407
Chemical Name: N-[2-(3,5-Dimethyl-1H-pyrazol-1-yl)
Biological ActivityPotent antagonist of adenosine A2A receptors; displays >100-fold selectivity for A2A over A1 receptors (Ki values are 0.44 and 85 nM respectively). Potentiates L-DOPA-induced rotational behavior in 6-OHDA-lesioned rats.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Zhang et al (2008) Lead optimization of 4-acetylamino-2-(3,5-dimethylpyrazol-1-yl)-6-pyridylpyrimidines as A2A adenosine receptor antagonists for the treatment of Parkinson's disease. J.Med.Chem. 51 7099. PMID: 18947224.
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Keywords: TC-G 1004, supplier, TC-G1004, adenosine, A2A, receptors, selective, potent, antagonists, Tocris Bioscience, Adenosine A2A Receptor Antagonist products
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