Cat. No. 4407
Chemical Name: N-[2-(3,5-Dimethyl-1H-pyrazol-1-yl)
Biological ActivityPotent antagonist of adenosine A2A receptors; displays >100-fold selectivity for A2A over A1 receptors (Ki values are 0.44 and 85 nM respectively). Potentiates L-DOPA-induced rotational behavior in 6-OHDA-lesioned rats.
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Certificate of Analysis / Product Datasheet / Safety Data Sheet
Zhang et al (2008) Lead optimization of 4-acetylamino-2-(3,5-dimethylpyrazol-1-yl)-6-pyridylpyrimidines as A2A adenosine receptor antagonists for the treatment of Parkinson's disease. J.Med.Chem. 51 7099. PMID: 18947224.
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Keywords: TC-G 1004, supplier, TC-G1004, adenosine, A2A, receptors, selective, potent, antagonists, Tocris Bioscience, Adenosine A2A Receptor Antagonist products