Cat. No. 4404
Chemical Name: 1-[(1,1'-Biphenyl)-4-ylmethyl]-5-(tr
Biological ActivitySelective positive allosteric modulator of M5 (EC50 values are 2.7 μM for human M5, and >30 μM for M1, M2, M3 and M4 receptors).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Bridges et al (2010) Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part I: development of the first highly selective M5 PAM. Bioorg.Med.Chem.Lett. 20 558. PMID: 20004578.
Bridges et al (2010) Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators. Bioorg.Med.Chem.Lett. 20 5617. PMID: 20801651.
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Keywords: VU 0365114, supplier, VU0365114, acetylcholine, muscarinics, machrs, receptors, positive, allosteric, modulators, pams, m5, Tocris Bioscience, M5 Receptor Modulator products
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