VU 0365114

Cat. No. 4404

VU 0365114 C22H14F3NO3 [1208222-39-2]

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Chemical Name: 1-[(1,1'-Biphenyl)-4-ylmethyl]-5-(trifluoromethoxy)-1H-indole-2,3-dione

Biological Activity

Selective positive allosteric modulator of M5 (EC50 values are 2.7 μM for human M5, and >30 μM for M1, M2, M3 and M4 receptors).

Technical Data

M.Wt:
397.35
Formula:
C22H14F3NO3
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
>98 %
Storage:
Store at RT
CAS No:
1208222-39-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Bridges et al (2010) Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part I: development of the first highly selective M5 PAM. Bioorg.Med.Chem.Lett. 20 558. PMID: 20004578.

Bridges et al (2010) Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators. Bioorg.Med.Chem.Lett. 20 5617. PMID: 20801651.

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Keywords: VU 0365114, supplier, VU0365114, acetylcholine, muscarinics, machrs, receptors, positive, allosteric, modulators, pams, m5, Tocris Bioscience, M5 Receptor Modulator products

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