Cat. No. 4403
Chemical Name: N-Hydroxy-N'-3-pyridinyloctanediamid
Biological ActivityInhibitor of histone deacetylase (HDAC); potently inhibits affinity purified HDAC1. Also inhibits the growth of tumor cells in vitro and in vivo. Induces p21/WAF1 expression in tumor cells.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Bradner et al (2010) Chemical phylogenetics of histone deacetylases. Nat.Chem.Biol. 6 238. PMID: 20139990.
Remiszewski et al (2002) Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J.Med.Chem. 45 755. PMID: 11831887.
Butler et al (2001) Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase. Clin.Cancer Res. 7 962. PMID: 11309347.
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Keywords: Pyroxamide, supplier, Pyroxamide, hdac, histone, deacetylase, inhibitors, inhibits, epigenetics, Tocris Bioscience, Histone Deacetylase Inhibitor products