Cat. No. 4403
Chemical Name: N-Hydroxy-N'-3-pyridinyloctanediamid
Biological ActivityInhibitor of histone deacetylase (HDAC); potently inhibits affinity purified HDAC1. Also inhibits the growth of tumor cells in vitro and in vivo. Induces p21/WAF1 expression in tumor cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Bradner et al (2010) Chemical phylogenetics of histone deacetylases. Nat.Chem.Biol. 6 238. PMID: 20139990.
Remiszewski et al (2002) Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J.Med.Chem. 45 755. PMID: 11831887.
Butler et al (2001) Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase. Clin.Cancer Res. 7 962. PMID: 11309347.
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Keywords: Pyroxamide, supplier, Pyroxamide, hdac, histone, deacetylase, inhibitors, inhibits, epigenetics, Tocris Bioscience, Histone Deacetylase Inhibitor products
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