Cat. No. 4401
Chemical Name: 1-(3-Bromophenyl)-5-(2-furanylmethy
Biological ActivityInhibitor of formin homology 2 (FH2) domains. Prevents formin-mediated actin nucleation and barbed end elongation. Disrupts formin-dependent actin cytoskeletal structures in fission yeast and mammalian NIH 3T3 fibroblasts.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Poincloux et al (2011) Contractility of the cell rear drives invasion of breast tumor cells in 3D Matrigel. Proc.Natl.Acad.Sci.USA 108 1943. PMID: 21245302.
Rizvi et al (2009) Identification and characterization of a small molecule inhibitor of formin-mediated actin assembly. Chem.Biol. 16 1158. PMID: 19942139.
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Citations are publications that use Tocris products. Selected citations for SMIFH2 include:
Tornavaca et al (2015) ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation. J Neurosci 208 821. PMID: 25753039.
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Keywords: SMIFH2, supplier, SMIFH2, formins, homology, fh2, domains, inhibitors, inhibits, actin, nucleation, Tocris Bioscience, Actin products
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