Cat. No. 4401
Chemical Name: 1-(3-Bromophenyl)-5-(2-furanylmethy
Biological ActivityInhibitor of formin homology 2 (FH2) domains. Prevents formin-mediated actin nucleation and barbed end elongation. Disrupts formin-dependent actin cytoskeletal structures in fission yeast and mammalian NIH 3T3 fibroblasts.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Poincloux et al (2011) Contractility of the cell rear drives invasion of breast tumor cells in 3D Matrigel. Proc.Natl.Acad.Sci.USA 108 1943. PMID: 21245302.
Rizvi et al (2009) Identification and characterization of a small molecule inhibitor of formin-mediated actin assembly. Chem.Biol. 16 1158. PMID: 19942139.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for SMIFH2 include:
Tornavaca et al (2015) ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation. J Neurosci 208 821. PMID: 25753039.
Do you know of a great paper that uses SMIFH2 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: SMIFH2, supplier, SMIFH2, formins, homology, fh2, domains, inhibitors, inhibits, actin, nucleation, Tocris Bioscience, Actin products
Find multiple products by catalog number
April 10 - 13, 2017