Cat. No. 4399
Chemical Name: 3-[6-[[4-(Trifluoromethoxy)phenyl]a
Biological ActivityAllosteric inhibitor of Bcr-Abl tyrosine kinase activity (IC50 = 267 nM); inhibits proliferation and induces apoptosis in Bcr-Abl-expressing cells. Selective for Bcr-Abl over a panel of serine, threonine and tyrosine kinases. Non-ATP-competitive.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Zhang et al (2010) Targeting Bcr-Abl by combining allosteric with ATP-binding site inhibitors. Nature 463 501. PMID: 20072125.
Adrián et al (2006) Allosteric inhibitors of Bcr-abl-dependent cell proliferation. Nat.Chem.Biol. 2 95. PMID: 16415863.
Ohren & Sebolt-Leopold et al (2006) Inhibitors of Bcr-abl... breaking new ground again. Nat.Chem.Biol. 2 63. PMID: 16421581.
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Keywords: GNF 2, supplier, GNF2, bcrabl, bcr, abl, fusion, philadelphia, chromosome, antiproliferatives, apoptosis, inducers, chronic, myeloid, leukemia, leukaemia, allosteric, inhibits, inhibitors, selective, Tocris Bioscience, Abl Kinase Inhibitor products
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