Cat. No. 4399

GNF 2 C18H13F3N4O2 [778270-11-4]

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Chemical Name: 3-[6-[[4-(Trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide

Biological Activity

Allosteric inhibitor of Bcr-Abl tyrosine kinase activity (IC50 = 267 nM); inhibits proliferation and induces apoptosis in Bcr-Abl-expressing cells. Selective for Bcr-Abl over a panel of serine, threonine and tyrosine kinases. Non-ATP-competitive.

Technical Data

Soluble to 100 mM in DMSO and to 50 mM in ethanol
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Zhang et al (2010) Targeting Bcr-Abl by combining allosteric with ATP-binding site inhibitors. Nature 463 501. PMID: 20072125.

Adrián et al (2006) Allosteric inhibitors of Bcr-abl-dependent cell proliferation. Nat.Chem.Biol. 2 95. PMID: 16415863.

Ohren & Sebolt-Leopold et al (2006) Inhibitors of Bcr-abl... breaking new ground again. Nat.Chem.Biol. 2 63. PMID: 16421581.

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Keywords: GNF 2, supplier, GNF2, bcrabl, bcr, abl, fusion, philadelphia, chromosome, antiproliferatives, apoptosis, inducers, chronic, myeloid, leukemia, leukaemia, allosteric, inhibits, inhibitors, selective, Tocris Bioscience, Abl Kinase Inhibitor products

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