Cat. No. 4398
Chemical Name: (2E,6E)-2,6-Bis(4-pyridinylmethylen
Biological ActivityAllosteric inhibitor of Akt; interferes with pleckstrin homology domain binding to PIP3 and facilitates Akt ubiquitination. Exhibits anticancer activity in vitro and in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Jo et al (2011) Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination. Proc.Natl.Acad.Sci.USA 108 6486. PMID: 21464312.
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Citations are publications that use Tocris products. Selected citations for SC 66 include:
Hung et al (2015) p22phox confers resistance to cisplatin, by blocking its entry into the nucleus. J Cell Biol 6 4110. PMID: 25686830.
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Keywords: SC 66, supplier, SC66, akt, pkb, protein, kinase, b, inhibitors, inhibits, allosteric, dual, activity, inhibitory, Tocris Bioscience, Akt (Protein Kinase B) Inhibitor products
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