Cat. No. 4398
Chemical Name: (2E,6E)-2,6-Bis(4-pyridinylmethylen
Biological ActivityAllosteric inhibitor of Akt; interferes with pleckstrin homology domain binding to PIP3 and facilitates Akt ubiquitination. Exhibits anticancer activity in vitro and in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Jo et al (2011) Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination. Proc.Natl.Acad.Sci.USA 108 6486. PMID: 21464312.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses SC 66 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: SC 66, supplier, SC66, akt, pkb, protein, kinase, b, inhibitors, inhibits, allosteric, dual, activity, inhibitory, Tocris Bioscience, Akt (Protein Kinase B) Inhibitor products
Find multiple products by catalog number
New Products in this Area
Potent Nek2 inhibitorRoscovitine
Potent, selective cyclin-dependent kinase inhibitorEnzastaurin
Potent PKCβ inhibitorBMS 265246
Potent cdk1/2 inhibitorAutocamtide-2-related inhibitory peptide, myristoylated
CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibitory peptideMP A08
Selective ATP competitive SphK1 and 2 inhibitor; cell permeableAkti-1/2
Potent and selective dual Akt1 and 2 inhibitorVX 680
High affinity and selective Aurora kinase inhibitorImatinib mesylate
Potent and selective v-Abl tyrosine kinase inhibitor; also inhibits PDGFR and c-kitTGX 221
Potent and selective PI 3-kinase β inhibitorPF 543 hydrochloride
Potent and selective SphK1 inhibitorJX 06
Potent and selective pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitorMRT 68601 hydrochloride
Potent TBK1 inhibitorAzoramide
Unfolded protein response (UPR) modulator
November 12 - 16, 2016
San Diego, CA, USA