SC 66

Cat. No. 4398

SC 66 C18H16N2O [871361-88-5]

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Chemical Name: (2E,6E)-2,6-Bis(4-pyridinylmethylene)cyclohexanone

Biological Activity

Allosteric inhibitor of Akt; interferes with pleckstrin homology domain binding to PIP3 and facilitates Akt ubiquitination. Exhibits anticancer activity in vitro and in vivo.

Technical Data

M.Wt:
276.33
Formula:
C18H16N2O
Solubility:
Soluble to 75 mM in DMSO and to 75 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
871361-88-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Jo et al (2011) Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination. Proc.Natl.Acad.Sci.USA 108 6486. PMID: 21464312.

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Citations are publications that use Tocris products. Selected citations for SC 66 include:

Hung et al (2015) p22phox confers resistance to cisplatin, by blocking its entry into the nucleus. J Cell Biol 6 4110. PMID: 25686830.

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Keywords: SC 66, supplier, SC66, akt, pkb, protein, kinase, b, inhibitors, inhibits, allosteric, dual, activity, inhibitory, Tocris Bioscience, Akt (Protein Kinase B) Inhibitor products

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