Cat. No. 4397
Chemical Name: N-[4-[(3-Chloro-4-fluorophenyl)amin
Biological ActivityPotent inhibitor of EGFR, ErbB2 and Abl receptor tyrosine kinases (IC50 values are 0.5-2, 19 and 41 nM, respectively). Also weak inhibitor of FLT1 and Src. Inhibits EGFR and ErbB2 autophosphorylation in vitro in NSCLC and T-47D breast cancer cell lines, respectively. Inhibits tumor growth of EGFR-overexpressing A431 and ErbB2 overexpressing BT-474 tumor xenografts in mice.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Suzuki et al (2009) Antitumor activity of a dual epidermal growth factor receptor and ErbB2 kinase inhibitor MP-412 (AV-412) in mouse xenograft models. Cancer Sci. 100 1526. PMID: 19459856 .
Suzuki et al (2007) Pharmacological characterization of MP-412 (AV-412), a dual epidermal growth factor receptor and ErbB2 tyrosine kinase inhibitor. Cancer Sci. 98 1977. PMID: 17888033 .
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Keywords: AV 412, supplier, AV412, epidermal, growth, factor, receptor, tyrosine, kinases, EGFR, ErbB2, RTKs, inhibitors, inhibits, potent, Abl, Tocris Bioscience, EGFR Inhibitor products
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