Cat. No. 4394
Chemical Name: 3-Fluoro-5-(2-methyl-5-benzothiazol
Biological ActivityPotent negative allosteric modulator of mGlu5 (IC50 = 61 nM). Displays no activity at mGlu1-4 and mGlu7-8.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Lindsley et al (2011) (3-cyano-5-fluorophenyl)biaryl negative allosteric modulators of mGlu5: discovery of a new tool compound with activity in the OSS mouse model of addiction. ACS Chem.Neurosci. 2 471. PMID: 21927650.
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Keywords: VU 0360223, supplier, VU0360223, potent, negative, allosteric, modulators, nams, mglu5, Tocris Bioscience, Glutamate (Metabotropic) Group I Receptor Modulator products