Thiamet G

Cat. No. 4390

Thiamet G C9H16N2O4S [1009816-48-1]

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Chemical Name: (3aR,5R,6S,7R,7aR)-2-(Ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-5H-pyrano[3,2-d]thiazole-6,7-diol

Biological Activity

Potent, selective inhibitor of O-GlcNAcase (Ki = 21 nM for human O-GlcNAcase). Decreases the phosphorylation of tau protein in vivo. Orally bioavailable and blood brain barrier permeable.

Technical Data

M.Wt:
248.3
Formula:
C9H16N2O4S
Solubility:
Soluble to 50 mM in DMSO
Storage:
Store at -20°C
CAS No:
1009816-48-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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Yuzwa et al (2008) A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. Nat.Chem.Biol. 4 483. PMID: 18587388.

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Citations are publications that use Tocris products. Selected citations for Thiamet G include:

Hayakawa et al (2013) Epigenetic switching by the metabolism-sensing factors in the generation of orexin neurons from mouse embryonic stem cells. J Biol Chem 288 17099. PMID: 23625921.

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Keywords: Thiamet G, supplier, glycosidase, O-GlcNAc-beta-N-acetylglucosaminidase, inhibitors, inhibits, O-GlcNAcase, ThiametG, Tocris Bioscience, Other Hydrolase Inhibitor products

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