Cat. No. 4390
Chemical Name: (3aR,5R,6S,7R,7aR)-2-(Ethylamino)-3
Biological ActivityPotent, selective inhibitor of O-GlcNAcase (Ki = 21 nM for human O-GlcNAcase). Decreases the phosphorylation of tau protein in vivo. Orally bioavailable and blood brain barrier permeable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Yuzwa et al (2008) A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. Nat.Chem.Biol. 4 483. PMID: 18587388.
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Citations are publications that use Tocris products. Selected citations for Thiamet G include:
Hayakawa et al (2013) Epigenetic switching by the metabolism-sensing factors in the generation of orexin neurons from mouse embryonic stem cells. J Biol Chem 288 17099. PMID: 23625921.
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Keywords: Thiamet G, supplier, glycosidase, O-GlcNAc-beta-N-acetylglucosaminidase, inhibitors, inhibits, O-GlcNAcase, ThiametG, Tocris Bioscience, Other Hydrolase Inhibitor products