MNI 137

Cat. No. 4388

MNI 137 C15H9BrN4O [946619-21-2]

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Chemical Name: 4-(8-Bromo-2,3-dihydro-2-oxo-1H-1,5-benzodiazepin-4-yl)-2-pyridinecarbonitrile

Biological Activity

Selective negative allosteric modulator of group II mGlu receptors (IC50 values are 8.3 and 12.6 nM for human and rat mGlu2 inhibition of glutamate-induced calcium mobilization). Displays no activity at mGlu1, mGlu4, mGlu5 or mGlu8 receptors in a calcium mobilization assay.

Technical Data

M.Wt:
341.16
Formula:
C15H9BrN4O
Solubility:
Soluble to 50 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
946619-21-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Hemstapat et al (2007) A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors. J.Pharmacol.Exp.Ther. 322 254. PMID: 17416742.

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Keywords: MNI 137, supplier, MNI137, glutamate, mGluRs, receptors, group, II, negative, allosteric, modulators, NAMs, selective, Tocris Bioscience, Glutamate (Metabotropic) Group II Receptor Modulator products

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