Calhex 231 hydrochloride

Cat. No. 4387

Calhex 231 hydrochloride C25H27ClN2O.HCl [652973-93-8]

Price and Availability

For Calhex 231 hydrochloride pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 4-Chloro-N-[(1S,2S)-2-[[(1R)-1-(1-naphthalenyl)ethyl]amino]cyclohexyl]-benzamide hydrochloride

Biological Activity

Negative allosteric modulator of the calcium sensing receptor (CaSR). Blocks increases in [3H]inositol phosphate levels elicited by wild-type hCasR activation (IC50= 0.39 μM in transiently transfected HEK293 cells).

Technical Data

M.Wt:
443.41
Formula:
C25H27ClN2O.HCl
Solubility:
Soluble to 50 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
652973-93-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Weston et al (2008) The expression and function of Ca2+-sensing receptors in rat mesenteric artery; comparative studies using a model of type II diabetes. Br.J.Pharmacol. 154 652. PMID: 18414396.

Kessler et al (2006) N1-Benzoyl-N2-[1-(1-naphthyl)ethyl]-trans-1,2-diaminocyclohexanes: Development of 4-chlorophenylcarboxamide (Calhex 231) as a new calcium sensing receptor ligand demonstrating potent calcilytic activity. J.Med.Chem. 49 5119. PMID: 16913701.

Petrel et al (2003) Modeling and mutagenesis of the binding site of Calhex 231, a novel negative allosteric modulator of the extracellular Ca2+-sensing receptor. J.Biol.Chem. 278 49487. PMID: 14506236.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses Calhex 231 hydrochloride from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: Calhex 231 hydrochloride, supplier, Calhex231, calcilytics, hcasr, calcium-sensing, receptors, negative, allosteric, modulators, nams, Tocris Bioscience, Calcium-Sensing Receptor Modulator products

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

NPG

Highlights 130 new products added in the first half of 2015. View PDF today.

divider line

New Products in this Area

SAR 216471 hydrochloride

Potent P2Y12 antagonist; cell permeable

A 971432

Potent and selective S1P5 agonist

GLPG 0974

Potent FFA2 antagonist

Ogerin

Selective positive allosteric modulator at GPR68

BGC 20-1531 hydrochloride

High affinity and selective EP4 antagonist

Montelukast sodium

CysLT1 antagonist

Beraprost sodium

Potent prostacyclin IP receptor agonist

JNJ 63533054

Potent and selective GPR139 agonist

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.