Cat. No. 4386
Chemical Name: 5-[5-Methyl-2-(1-methylethyl)phenox
Biological ActivitySelective P2X3 and P2X2/3 receptor antagonist (pIC50 values are 7.39 and 6.68 respectively). Displays no detectable activity at P2X1, P2X2, P2X4 and P2X7 receptors (pIC50 < 4.7).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Ballini et al (2011) Characterization of three diaminopyrimidines as potent and selective antagonists of P2X3 and P2X2/3 receptors with in vivo efficacy in a pain model. Br.J.Pharmacol. 163 1315. PMID: 21410458.
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Keywords: TC-P 262, supplier, Selective, P2X3, P2X2/3, receptors, antagonists, TC-P262, Tocris Bioscience, Purinergic (P2X) Receptor Antagonist products
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June 14 - 17, 2017
Boston, MA, USA