Cat. No. 4385
Alternative Name: E 2020
Chemical Name: 2,3-Dihydro-5,6-dimethoxy-2-[[1-(ph
Biological ActivityPotent acetylcholinesterase inhibitor (IC50 = 5.7 nM). Displays 1252-fold selectivity for AChE over BuChE (IC50 = 7138 nM for BuChE). Orally active.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Sugimoto et al (2000) Donepezil hydrochloride (E2020) and other acetylcholinesterase inhibitors. Curr.Med.Chem. 7 303. PMID: 10637367.
Kryger et al (1999) Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs. Structure 7 297. PMID: 10368299.
Sugimoto et al (1995) Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds. J.Med.Chem. 38 4821. PMID: 7490731.
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Citations are publications that use Tocris products. Selected citations for Donepezil hydrochloride include:
Morris et al (2015) Network dysfunction in α-synuclein transgenic mice and human Lewy body dementia. Ann Clin Transl Neurol 2 1012. PMID: 26732627.
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Keywords: Donepezil hydrochloride, supplier, acetylcholinesterase, ache, selective, potent, inhibitors, inhibits, E2020, Tocris Bioscience, Cholinesterase Inhibitor products