Donepezil hydrochloride

Cat. No. 4385

Donepezil hydrochloride C24H29NO3.HCl [120011-70-3]

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Alternative Name: E 2020

Chemical Name: 2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride

Biological Activity

Potent acetylcholinesterase inhibitor (IC50 = 5.7 nM). Displays 1252-fold selectivity for AChE over BuChE (IC50 = 7138 nM for BuChE). Orally active.

Technical Data

M.Wt:
415.95
Formula:
C24H29NO3.HCl
Solubility:
Soluble to 75 mM in water and to 10 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
120011-70-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Sugimoto et al (2000) Donepezil hydrochloride (E2020) and other acetylcholinesterase inhibitors. Curr.Med.Chem. 7 303. PMID: 10637367.

Kryger et al (1999) Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs. Structure 7 297. PMID: 10368299.

Sugimoto et al (1995) Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds. J.Med.Chem. 38 4821. PMID: 7490731.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Donepezil hydrochloride include:

Morris et al (2015) Network dysfunction in α-synuclein transgenic mice and human Lewy body dementia. Ann Clin Transl Neurol 2 1012. PMID: 26732627.

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Keywords: Donepezil hydrochloride, supplier, acetylcholinesterase, ache, selective, potent, inhibitors, inhibits, E2020, Tocris Bioscience, Cholinesterase Inhibitor products

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