VU 0285683

Cat. No. 4381

VU 0285683 C14H7FN4O [327056-22-4]

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Chemical Name: 3-Fluoro-5-[3-(2-pyridinyl)-1,2,4-oxadiazol-5-yl]-benzonitrile

Biological Activity

Negative allosteric modulator of mGlu5 receptors. Displays high affinity for the MPEP (Cat. No. 1212) binding site; acts as a full antagonist and blocks the glutamate response to mGlu5 (IC50 = 24.4 nM). Selective for mGlu5 over mGlu1, mGlu3 and mGlu4. Exhibits anxiolytic activity in rodent models of anxiety. Analog available (Cat. No. 4323).

Technical Data

M.Wt:
266.23
Formula:
C14H7FN4O
Solubility:
Soluble to 50 mM in DMSO and to 25 mM in ethanol
Purity:
>98 %
Storage:
Store at RT
CAS No:
327056-22-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Rodriguez (2010) Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol.Pharmacol. 78 (6) 1105. PMID: 20923853.

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Citations are publications that use Tocris products.

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Keywords: VU 0285683, supplier, Negative, allosteric, modulators, mGlu5, mGluR5, mGlur, Group, I, Receptors, Glutamate, Metabotropic, MPEP, binding, site, VU0285683, nams, Tocris Bioscience, Glutamate (Metabotropic) Group I Receptor Modulator products

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