DLPC

Cat. No. 4378

DLPC C32H64NO8P [18194-25-7]

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Chemical Name: (7R)-4-Hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxododecyl)oxy]-3,5,9-trioxa-4-phosphaheneicosan-1-aminium-4-oxide

Biological Activity

Selective agonist of the orphan nuclear receptor LRH-1 (liver receptor homolog-1, NR5A2) in vitro. Induces bile acid biosynthetic enzymes; increases bile acid and decreases hepatic triglycerides and serum glucose. Exhibits antidiabetic effects.

Technical Data

M.Wt:
621.83
Formula:
C32H64NO8P
Solubility:
Soluble to 100 mM in ethanol
Storage:
Store at -20°C
CAS No:
18194-25-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Lee et al (2011) A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects. Nature 474 506. PMID: 21614002.

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Citations are publications that use Tocris products. Selected citations for DLPC include:

Zhu et al (2014) Mouse liver repopulation with hepatocytes generated from human fibroblasts. Nature 508 93. PMID: 24572354.

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Keywords: DLPC, supplier, Dilauroyl, phosphatidylcholine, LRH-1, agonist, orphan, nuclear, receptor, agonists, NR5A2, saturated, fatty, acid, chain, liver, receptor, homolog, homologue, Tocris Bioscience, Other Lipid Metabolism products

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