Cat. No. 4378
Chemical Name: (7R)-4-Hydroxy-N,N,N-trimethyl-10-o
Biological ActivitySelective agonist of the orphan nuclear receptor LRH-1 (liver receptor homolog-1, NR5A2) in vitro. Induces bile acid biosynthetic enzymes; increases bile acid and decreases hepatic triglycerides and serum glucose. Exhibits antidiabetic effects.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Lee et al (2011) A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects. Nature 474 506. PMID: 21614002.
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Keywords: DLPC, supplier, Dilauroyl, phosphatidylcholine, LRH-1, agonist, orphan, nuclear, receptor, agonists, NR5A2, saturated, fatty, acid, chain, liver, receptor, homolog, homologue, Tocris Bioscience, Other Lipid Metabolism products