SMER 3

Cat. No. 4375

SMER 3 C11H4N4O2 [67200-34-4]

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Chemical Name: 9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one

Biological Activity

Selective inhibitor of a yeast SCF family E3 ubiquitin ligase (SCFMet30) in vitro and in vivo. Induces the expression of MET genes; blocks cell proliferation. Enhancer of rapamycin (Cat. No. 1292).

Technical Data

M.Wt:
224.18
Formula:
C11H4N4O2
Solubility:
Soluble to 75 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
67200-34-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Aghajanyy et al (2010) Chemical genetics of TOR identifies an SCF family E3 ubiquitin ligase inhibitor. Nat.Biotechnol. 28 738. PMID: 20581845.

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Keywords: SMER 3, supplier, SMER3, ubiquitin, E3, ligase, inhibitors, inhibits, Ub, ligases, small-molecule, enhancers, rapamycin, SCF, family, Tocris Bioscience, Ubiquitin E3 Ligase Inhibitor products

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