Cat. No. 4374
Chemical Name: 2,3-Dihydro-N-[(3-endo)-8-methyl-8-
Biological ActivityPotent 5-HT4 receptor full agonist (KD = 77 nM and EC50 = 18 nM for wild type 5-HT4 receptors). Binds to receptors in a mechanism different to that of the endogenous ligand 5-HT.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Pellissier et al (2009) Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors. Mol.Pharmacol. 75 982. PMID: 19168624.
Schaus et al (1998) Synthesis and structure-activity relationships of potent and orally active 5-HT4 receptor antagonists: Indazole and benzimidazoline derivatives. J.Med.Chem. 41 1943. PMID: 9599243.
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Keywords: BIMU 8, supplier, BIMU8, 5-hydroxytryptamine, 4, 5HT4, receptors, 5-HT4, receptors, agonists, serotonin, serotonergic, 4, Tocris Bioscience, 5-HT4 Receptor Agonist products
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December 3 - 7, 2016
San Francisco, CA,