Cat. No. 4374

BIMU 8 C19H26N4O2.HCl [134296-40-5]

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Chemical Name: 2,3-Dihydro-N-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-3-(1-methylethyl)-2-oxo-1H-benzimidazole-1-carboxamide hydrochloride

Biological Activity

Potent 5-HT4 receptor full agonist (KD = 77 nM and EC50 = 18 nM for wild type 5-HT4 receptors). Binds to receptors in a mechanism different to that of the endogenous ligand 5-HT.

Technical Data

Soluble to 75 mM in water and to 100 mM in DMSO
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Pellissier et al (2009) Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors. Mol.Pharmacol. 75 982. PMID: 19168624.

Schaus et al (1998) Synthesis and structure-activity relationships of potent and orally active 5-HT4 receptor antagonists: Indazole and benzimidazoline derivatives. J.Med.Chem. 41 1943. PMID: 9599243.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for BIMU 8 include:

House et al (2015) Genetic variation in HTR4 and lung function: GWAS follow-up in mouse. PLoS One 29 323. PMID: 25342126.

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Keywords: BIMU 8, supplier, BIMU8, 5-hydroxytryptamine, 4, 5HT4, receptors, 5-HT4, receptors, agonists, serotonin, serotonergic, 4, Tocris Bioscience, 5-HT4 Receptor Agonist products

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