Cat. No. 4374
Chemical Name: 2,3-Dihydro-N-[(3-endo)-8-methyl-8-
Biological ActivityPotent 5-HT4 receptor full agonist (KD = 77 nM and EC50 = 18 nM for wild type 5-HT4 receptors). Binds to receptors in a mechanism different to that of the endogenous ligand 5-HT.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Pellissier et al (2009) Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors. Mol.Pharmacol. 75 982. PMID: 19168624.
Schaus et al (1998) Synthesis and structure-activity relationships of potent and orally active 5-HT4 receptor antagonists: Indazole and benzimidazoline derivatives. J.Med.Chem. 41 1943. PMID: 9599243.
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Citations are publications that use Tocris products. Selected citations for BIMU 8 include:
Wang et al (2016) 5-HTR3 and 5-HTR4 located on the mitochondrial membrane and functionally regulated mitochondrialfunctions Scientific Reports 6 37336. PMID: 27874067.
House et al (2015) Genetic variation in HTR4 and lung function: GWAS follow-up in mouse. PLoS One 29 323. PMID: 25342126.
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Keywords: BIMU 8, supplier, BIMU8, 5-hydroxytryptamine, 4, 5HT4, receptors, 5-HT4, receptors, agonists, serotonin, serotonergic, 4, Tocris Bioscience, 5-HT4 Receptor Agonist products
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April 1 - 5, 2017
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