Cat. No. 4373

CMPDA C16H28N2O4S2 [380607-77-2]

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Chemical Name: N,N'-(1,4-Phenylenedi-2,1-ethanediyl)bis-2-propanesulfonamide

Biological Activity

Positive allosteric modulator of GluR2 receptors (EC50 values are 45.4 and 63.4 nM at GluR2i and GluR2o respectively, in a calcium influx screening assay). Binds at the modulator binding pocket located at the interdimer interface and the clamshell hinges.

Technical Data

Soluble to 100 mM in DMSO and to 50 mM in ethanol
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Timm et al (2011) Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation. Mol.Pharmacol. 80 267. PMID: 21543522.

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Keywords: CMPDA, supplier, Positive, allosteric, modulators, GluR2, GluA2, AMPA, receptors, GluR2i, GluA2i, GluR2o, GluA2o, Tocris Bioscience, AMPA Receptor Modulator products

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