BC 11 hydrobromide

Cat. No. 4372

BC 11 hydrobromide C8H11BN2O2S.HBr [443776-49-6]

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Chemical Name: Carbamimidothioic acid (4-boronophenyl)methyl ester hydrobromide

Biological Activity

Selective urokinase (uPA) inhibitor (IC50 = 8.2 μM). Exhibits no activity at 8 other related enzymes. Inhibits clot lysis with no effect on clot formation. Also decreases viability of MDA-MB231 breast cancer cells in vitro.

Technical Data

Soluble to 100 mM in DMSO and to 20 mM in water with gentle warming
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Longo et al (2015) Cytotoxicity of the Urokinase-Plasminogen Activator Inhibitor Carbamimidothioic Acid (4-Boronophenyl) Methyl Ester Hydrobromide (BC-11) on Triple-Negative MDA-MB231 Breast Cancer Cells Molecules 20 9879. PMID: 26029857.

Smith et al (2011) Elucidating novel urokinase-type plasminogen activator inhibitors. Int.Soc.Thromb.Haemost. (Abstract) 9 819.

If you know of a relevant reference for BC 11 hydrobromide please let us know.

Citations are publications that use Tocris products. Selected citations for BC 11 hydrobromide include:

Semina et al (2016) Urokinase and urokinase receptor participate in regulation of neuronal migration, axon growth and branching. Eur.J.Cell Biol. 95 295. PMID: 27324124.

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Keywords: BC 11 hydrobromide, supplier, BC11, HBr, urokinase, inhibitor, inhibits, uPA, urokinase-type, plasminogen-activator, inhibitors, Tocris Bioscience, Urokinase Inhibitor products

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