VU 0364439

Cat. No. 4371

VU 0364439 C18H13Cl2N3O3S [1246086-78-1]

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Chemical Name: N-[3-Chloro-4-[[(2-chlorophenyl)amino]sulfonyl]phenyl]-2-pyridinecarboxamide

Biological Activity

Positive allosteric modulator (PAM) of mGlu4 receptors (EC50 = 19.8 nM in vitro for human mGlu4).

Technical Data

M.Wt:
422.29
Formula:
C18H13Cl2N3O3S
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
1246086-78-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Robichaud et al (2011) Recent progress on the identification of metabotropic glutamate 4 receptor ligands and their potential utility as CNS therapeutics. ACS Chem.Neurosci. 2 433.

Engers et al (2010) Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS). Bioorg.Med.Chem.Lett. 20 5175. PMID: 20667732.

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Citations are publications that use Tocris products.

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Keywords: VU 0364439, supplier, VU0364439, potent, mGlu4, mGluR4, postive, allosteric, modulators, PAMs, metabotropic, glutamate, 4, receptors, Tocris Bioscience, Glutamate (Metabotropic) Group III Receptor Modulator products

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