Cat. No. 4371
Chemical Name: N-[3-Chloro-4-[[(2-chlorophenyl)ami
Biological ActivityPositive allosteric modulator (PAM) of mGlu4 receptors (EC50 = 19.8 nM in vitro for human mGlu4).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Robichaud et al (2011) Recent progress on the identification of metabotropic glutamate 4 receptor ligands and their potential utility as CNS therapeutics. ACS Chem.Neurosci. 2 433.
Engers et al (2010) Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS). Bioorg.Med.Chem.Lett. 20 5175. PMID: 20667732.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses VU 0364439 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: VU 0364439, supplier, VU0364439, potent, mGlu4, mGluR4, postive, allosteric, modulators, PAMs, metabotropic, glutamate, 4, receptors, Tocris Bioscience, Glutamate (Metabotropic) Group III Receptor Modulator products