Cat. No. 4370
Chemical Name: 4,5,6,8-Tetrahydro-N-2-pyridinylpyr
Biological ActivityPotent and selective mGlu4 receptor positive allosteric modulator (EC50 = 9 nM in human mGlu4-expressing BHK cells). Selective for mGlu4 over mGlu1, mGlu2, mGlu3, mGlu5 and mGlu7 receptors (EC50 values are > 10 μM). Brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Hong et al (2011) Tricyclic thiazolopyrazole derivatives as metabotropic glutamate receptor 4 positive allosteric modulators. J.Med.Chem. 54 5070. PMID: 21688779.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses TC-N 22A from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: TC-N 22A, supplier, metabotropics, glutamate, 4, receptors, positive, allosteric, modulators, brain, penetrant, mglur4, mglu, pams, TC-N22A, Tocris Bioscience, Glutamate (Metabotropic) Group III Receptor Modulator products
Find multiple products by catalog number
New Products in this Area
Negative allosteric modulator at mGlu7; brain penetrant
One Day Symposium
March 1, 2017
Amsterdam, The Netherlands