TC-N 22A

Cat. No. 4370

TC-N 22A C14H13N5S [1314140-00-5]

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Chemical Name: 4,5,6,8-Tetrahydro-N-2-pyridinylpyrazolo[3',4':6,7]cyclohepta[1,2]thiazol-2-amine

Biological Activity

Potent and selective mGlu4 receptor positive allosteric modulator (EC50 = 9 nM in human mGlu4-expressing BHK cells). Selective for mGlu4 over mGlu1, mGlu2, mGlu3, mGlu5 and mGlu7 receptors (EC50 values are > 10 μM). Brain penetrant.

Technical Data

M.Wt:
283.35
Formula:
C14H13N5S
Solubility:
Soluble to 50 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1314140-00-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Hong et al (2011) Tricyclic thiazolopyrazole derivatives as metabotropic glutamate receptor 4 positive allosteric modulators. J.Med.Chem. 54 5070. PMID: 21688779.

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Citations are publications that use Tocris products.

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Keywords: TC-N 22A, supplier, metabotropics, glutamate, 4, receptors, positive, allosteric, modulators, brain, penetrant, mglur4, mglu, pams, TC-N22A, Tocris Bioscience, Glutamate (Metabotropic) Group III Receptor Modulator products

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