Psora 4

Cat. No. 4367

Psora 4 C21H18O4 [724709-68-6]

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Chemical Name: 4-(4-Phenylbutoxy)-7H-furo[3,2-g][1]benzopyran-7-one

Biological Activity

Potent KV1.3 channel blocker (EC50 = 3 nM). Preferentially binds the C-type inactivated state of the channel, similar to the activity of CP 339818 (Cat. No. 1399). Displays 17- to 70-fold selectivity over closely-related KV1 channels (KV1, KV2, KV4 and KV7); exhibits activity at KV1.5 (IC50 = 7.7 nM). Suppresses proliferation of human and rat myelin-specific effector memory T cells (EC50 values are 25 and 60 nM respectively).

Technical Data

Soluble to 50 mM in DMSO and to 10 mM in ethanol
>99 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Li et al (2006) Voltage-gated potassium channel Kv1.3 regulates GLUT4 trafficking to the plasma membrane via a Ca2+-dependent mechanism. Am.J.Physiol.Cell Physiol. 290 C345. PMID: 16403947.

Schmitz et al (2005) Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases. Mol.Pharmacol. 68 1254. PMID: 16099841.

Vennekamp et al (2004) Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators. Mol.Pharmacol. 65 1364. PMID: 15155830.

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Keywords: Psora 4, supplier, Psora4, Kv1.3, selective, ion, channels, blockers, potent, KV13, Potassium, KV, voltage-gated, voltage-dependent, K+, Tocris Bioscience, Voltage-gated Potassium (KV) Channel Blocker products

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