Cat. No. 4365
Chemical Name: 4-[(4-Fluorophenyl)methoxy]-1-[4-[2
Biological ActivityPotent, selective melanin-concentrating hormone receptor 1 (MCH1R) antagonist (IC50= 5.6 nM in hMCH1R-expressing CHO cells). Displays selectivity for MCH1R over MCH2R (IC50 = > 10 μM). Decreases body weight in a mouse model of diet-induced obesity. Brain penetrant; orally active.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Haga et al (2011) Discovery of novel phenylpyridone derivatives as potent and selective MCH1R antagonists. Bioorg.Med.Chem. 19 883. PMID: 21190859.
Ito et al (2009) Melanin-concentrating hormone 1-receptor antagonist suppresses body weight gain correlated with high receptor occupancy levels in diet-induced obesity mice. Eur.J.Pharmacol. 624 77. PMID: 19836369.
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Keywords: TC-MCH 7c, supplier, TCMCH7c, obese, potent, selective, MCH, MCHR, MCH1R, MCHR1, antagonists, melanin, concentrating, hormones, receptors, Tocris Bioscience, Melanin-concentrating Hormone Receptor Antagonist products
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