TC-MCH 7c

Cat. No. 4365

TC-MCH 7c C24H25FN2O3 [864756-35-4]

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Chemical Name: 4-[(4-Fluorophenyl)methoxy]-1-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-2(1H)-pyridinone

Biological Activity

Potent, selective melanin-concentrating hormone receptor 1 (MCH1R) antagonist (IC50= 5.6 nM in hMCH1R-expressing CHO cells). Displays selectivity for MCH1R over MCH2R (IC50 = > 10 μM). Decreases body weight in a mouse model of diet-induced obesity. Brain penetrant; orally active.

Technical Data

M.Wt:
408.47
Formula:
C24H25FN2O3
Solubility:
Soluble to 100 mM in 1eq. HCl and to 50 mM in DMSO
Purity:
>97 %
Storage:
Store at RT
CAS No:
864756-35-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Haga et al (2011) Discovery of novel phenylpyridone derivatives as potent and selective MCH1R antagonists. Bioorg.Med.Chem. 19 883. PMID: 21190859.

Ito et al (2009) Melanin-concentrating hormone 1-receptor antagonist suppresses body weight gain correlated with high receptor occupancy levels in diet-induced obesity mice. Eur.J.Pharmacol. 624 77. PMID: 19836369.

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Keywords: TC-MCH 7c, supplier, TCMCH7c, obese, potent, selective, MCH, MCHR, MCH1R, MCHR1, antagonists, melanin, concentrating, hormones, receptors, Tocris Bioscience, Melanin-concentrating Hormone Receptor Antagonist products

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