Cat. No. 4362
Chemical Name: (αR)-4-(2-Fluoro-4-methoxyphenyl)-N-
Biological ActivityPotent antibacterial agent which disrupts lipid bilayer synthesis through inhibition of LpxC (IC50 = 1.1 nM in Pseudomonas aeruginosa); effective against a range of gram negative bacteria.
Licensing InformationSold for research purposes under agreement from Pfizer Inc.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Montgomery et al (2012) Pyridone methylsulfone hydroxamate LpxC inhibitors for the treatment of serious gram-negative infections. J.Med.Chem. 55 (4) 1662. PMID: 22257165.
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Keywords: PF 5081090, supplier, antibacterials, gram, negative, LxpC, lipid, A, bilayer, synthesis, inhibits, inhibitors, potent, pfizer, PF5081090, Tocris Bioscience, Antibiotic products
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