PF 5081090

Cat. No. 4362

PF 5081090 C18H21FN2O6S [1312473-63-4]

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Chemical Name: (αR)-4-(2-Fluoro-4-methoxyphenyl)-N-hydroxy-α-methyl-α-(methylsulfonyl)-2-oxo-1(2H)-pyridinebutanamide

Biological Activity

Potent antibacterial agent which disrupts lipid bilayer synthesis through inhibition of LpxC (IC50 = 1.1 nM in Pseudomonas aeruginosa); effective against a range of gram negative bacteria.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M.Wt:
412.43
Formula:
C18H21FN2O6S
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1312473-63-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Montgomery et al (2012) Pyridone methylsulfone hydroxamate LpxC inhibitors for the treatment of serious gram-negative infections. J.Med.Chem. 55 (4) 1662. PMID: 22257165.

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Keywords: PF 5081090, supplier, antibacterials, gram, negative, LxpC, lipid, A, bilayer, synthesis, inhibits, inhibitors, potent, pfizer, PF5081090, Tocris Bioscience, Antibiotic products

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