Bicifadine hydrochloride

Cat. No. 4357

Bicifadine hydrochloride C12H15N.HCl [66504-75-4]

Price and Availability

For Bicifadine hydrochloride pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 1-(4-Methylphenyl)-3-azabicyclo[3.1.0]hexane hydrochloride

Biological Activity

Potent antagonist of the noradrenalin transporter (IC50 = 55 nM); also displays antagonist activity at the 5-HT and dopamine transporters (IC50 values are 117 nM and 910 nM respectively). Orally active. Exhibits antinociceptive and antiallodynic activity in rodent models of acute, persistent, and chronic pain.

Technical Data

M.Wt:
209.72
Formula:
C12H15N.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
66504-75-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Basile (2007) Characterization of the antinociceptive actions of bicifadine in models of acute, persistent, and chronic pain. J.Pharmacol.Exp.Ther 321 (3) 1208. PMID: 17325229.

Epstein (1981) 1-Aryl-3-azabicyclo[3.1.0]hexanes, a new series of nonnarcotic analgesic agents. J.Med.Chem. 24 (5) 481. PMID: 7241504.

If you know of a relevant reference for Bicifadine hydrochloride please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses Bicifadine hydrochloride from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Bicifadine hydrochloride, supplier, norepinephrine, noradrenalin, noradrenaline, transporters, serotonin, serotonergics, 5-HT, SERT, reuptake, inhibitors, inhibits, NET, DAT, dopamine, Tocris Bioscience, Adrenergic Transporter Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Our Cardiovascular Guide highlights over 250 products for cardiovascular research. Request copy or view PDF today.

divider line

New Products in this Area

(R)-Modafinil

Dopamine uptake inhibitor

Sign-up for new product e-alerts
divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.