Bicifadine hydrochloride

Cat. No. 4357

Bicifadine hydrochloride C12H15N.HCl [66504-75-4]

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Chemical Name: 1-(4-Methylphenyl)-3-azabicyclo[3.1.0]hexane hydrochloride

Biological Activity

Potent antagonist of the noradrenalin transporter (IC50 = 55 nM); also displays antagonist activity at the 5-HT and dopamine transporters (IC50 values are 117 nM and 910 nM respectively). Orally active. Exhibits antinociceptive and antiallodynic activity in rodent models of acute, persistent, and chronic pain.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
>98 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Basile (2007) Characterization of the antinociceptive actions of bicifadine in models of acute, persistent, and chronic pain. J.Pharmacol.Exp.Ther 321 (3) 1208. PMID: 17325229.

Epstein (1981) 1-Aryl-3-azabicyclo[3.1.0]hexanes, a new series of nonnarcotic analgesic agents. J.Med.Chem. 24 (5) 481. PMID: 7241504.

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Keywords: Bicifadine hydrochloride, supplier, norepinephrine, noradrenalin, noradrenaline, transporters, serotonin, serotonergics, 5-HT, SERT, reuptake, inhibitors, inhibits, NET, DAT, dopamine, Tocris Bioscience, Adrenergic Transporter Inhibitor products

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