Cat. No. 4355
Chemical Name: 1-[(3S)-1-[4-(2-Benzofuranyl)-2-pyr
Biological ActivityPotent, reversible inhibitor of fatty acid amide hydrolase (FAAH) (IC50 values are 28 and 100 nM for human and rat FAAH respectively). Noncovalent inhibitor; displays selectivity for FAAH over cannabinoid-related targets (IC50 > 20 μM for CB1, CB2 and TRPV1). Active in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Gustin et al (2011) Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors. Bioorg.Med.Chem.Lett. 21 2492. PMID: 21392988.
Min et al (2011) Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH). Proc.Natl.Acad.Sci.U.S.A. 108 7379. PMID: 21502526.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses TC-F 2 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: TC-F 2, supplier, TCF2, TC-F2, fatty, acid, amide, hydrolase, FAAH, inhibits, inhibitors, reversible, noncovalent, potent, in, vivo, selective, Tocris Bioscience, FAAH Inhibitor products
Find multiple products by catalog number
New Products in this Area
Non-competitive MAGL inhibitor(S)-Crizotinib
Potent MTH1 inhibitorTPPU
Potent soluble epoxide hydrolase inhibitor; orally bioavailable and brain penetrantJZP 430
Potent and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.