TC-G 24

Cat. No. 4353

TC-G 24 C15H11ClN4O3 [1257256-44-2]

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Chemical Name: N-(3-Chloro-4-methylphenyl)-5-(4-nitrophenyl)-1,3,4-oxadiazol-2-amine

Biological Activity

Potent GSK-3β inhibitor (IC50 = 17 nM); displays selectivity for GSK-3β over CDK2 (22% inhibition at 10 μM). Increases liver glycogen reserves in rodents. Brain penetrant.

Technical Data

Soluble to 10 mM in DMSO with gentle warming
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Khanfar et al (2010) Discovery of novel GSK-3β inhibitors with potent in vitro and in vivo activities and excellent brain permeability using combined ligand- and structure-based virtual screening. J.Med.Chem. 53 8534. PMID: 21082766.

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Keywords: TC-G 24, supplier, TC-G24, glycogen, synthase, kinase, 3, beta, b, β, gsk3beta, gsk3β, potent, inhibits, inhibitors, selective, brain, penetrant, liver, hinge, region, binder, Tocris Bioscience, Glycogen Synthase Kinase 3 Inhibitor products

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